Welcome from the Center Director

Farkhondeh Behjati

PhD: Tehran University of Medical Sciences

Dip .R.C. Path: The Royal College of Pathologists, England

Professor of Medical Genetics

e-mail: fbehjati@gmail.com


Tel. No.: 0098-21-22180138

Address: Genetics Research Center- University of Social Welfare and Rehabilitation- Kudakyar Alley- Daneshju Blvd.- Evin- Tehran- Iran

Link in scopus: http://www.scopus.com/authid/detail.url?origin=AuthorProfile&authorId=12242044600&zone=

Link in google scholar: https://scholar.google.com/citations?hl=en&user=XuvzJAoAAAAJ&view_op=list_works

Research Interests:

We use Classic Cytogenetic techniques, Fluorescent In Situ Hybridization (FISH), MLPA, and Array CGH techniques to study chromosome abnormalities both numerical and structural, chromosome breakage as well as copy number variation in a wide range of conditions with Genetic etiology. These conditions include Intellectual disabilities, Autism, Multiple Congenital Anomalies, Breast Cancer, Individuals exposed to pollutants and carcinogens, and Neurodegenerative disorders.  


Current research Projects:

Evaluation of genomic imbalances in 50 Iranian patients with Idiopathic Autism and Intellectual disability using  MLPA and Array CGH

Investigation of  chromosomal abnormalities and determination of  their hereditary status in patients with multiple congenital abnormalities using karyotyping and array-CGH

Investigation of miRNA Expression Profile in the plasma of patients with Parkinson’s Disease as an early potential diagnostic biomarker

Investigation of Copy Number Variation  in c-KIT Gene and its Expression, as an Angiogenesis Marker  in 50 Iranian Women  with Sporadic Breast Cancer

Selected publications

Najmabadi H, Hu H, Garshasbi M, Zemojtel T, Abedini SS, Chen W, Hosseini M, Behjati F, …, Kahrizi K, Ropers HH. Deep sequencing reveals 50 novel genes for recessive cognitive disorders. Nature. 2011 Sep 21;478(7367):57-63. doi: 10.1038/nature10423

Pazhoomand R, Keyhani E, …., and Behjati F. Detection of HER2 Status in Breast Cancer: Comparison of Current Methods with MLPA and Real-time RT-PCR. Asian Pac J Cancer Prev. 2013; 14(12):7621-8.

Farkhondeh Behjati, Saghar Ghasemi Firouzabadi,….. Roshanak Vameghi. Identification of Chromosome Abnormalities in Subtelomeric Regions Using Multiplex Ligation Dependent Probe Amplification (MLPA) technique in 100 Iranian Patients With Idiopathic Mental Retardation. Iranian Red Crescent Medical Journal. 2013 October; 15(10): e8221.

Farkhondeh Behjati, Saghar Ghasemi Firouzabadi,   Roxana Kariminejad, Firouzeh Sajedi,…… Hossein Najmabadi. Genomic characterization of some Iranian children with idiopathic mental retardation using array comparative genomic hybridization. Indian Journal of Human Genetics October-December 2013 Volume 19 Issue 4: 443-448.

Sara Taghizadeh, Hossein Najmabadi, Koorosh Kamali, and Farkhondeh Behjati. Evaluation of chromosomal aberrations caused by air pollutants in some taxi drivers from two polluted districts of urban Tehran and its comparison with drivers from rural areas of Lahijan: a pilot study. Journal of Environmental Health Science & Engineering (2014) 12:144.




Genetics Research Center
Iranome: Iranian Genomic Variations

The human genome is highly variable and each individual’s genome contains approximately 3.5 million Single Nucleotide Polymorphisms (SNPs) and 1000 large (>500 bp) Copy Number Variations (CNVs).

Today, large scale projects such as the 1000 Genomes and the International HapMap projects have been implemented on large scale samples from different populations such as Europeans, Americans, East Asians, and sub-Saharan Africans to increase our understanding of the contribution of genomic variations to human diseases. … more