Welcome from the Center Director

Mehdi Banan

PhD: University of Texas at Austin

Associate Professor

e-mail: mbbanan@yahoo.com

           me.banan@uswr.ac.ir

Tel. No.: 0098-21-22180138

Address: Genetics Research Center- University of Social Welfare and Rehabilitation- Kudakyar Alley- Daneshju Blvd.- Evin- Tehran- Iran

Link in scopus: http://www.scopus.com/authid/detail.url?origin=AuthorProfile&authorId=55404728100&zone=

Link in google scholar: https://scholar.google.com/citations?user=55mvY10AAAAJ&hl=en&oi=ao

 

Research Interests:

We are interested in understanding the differential response of β-thalassemia patients to the γ-globin inducing drug, hydroxyurea. We are also trying to understand why the severity of the β-thalassemia disorder varies between patients i.e. phenotype/genotype studies.

 

Current Projects:

Understanding the possible functional role of tag SNPs located in the BCL11A enhancer by using genome editing technology (CRISPR-Cas9) in model cell lines. 

 

Selected publications:

Banan M*, Esmaeilzadeh-Gharadaghi E, Nezami M, Deilami Z, Farashi S, Philipsen S, Esteghamat F, Pourfarzad F, Imam AMA, and  Najmabadi H (2012) cAMP response element protein 1 is required for hydroxyurea-mediated induction of γ-globin expression in K562 cells. Clin Exp Pharmacol Physiol. 39(6): 510-517. 

Banan M*, Bayat H, Azarkeivan A, Mohammadparast S, Farashi S, Hadavand-Khani M, Neishabury M, and Najmabadi H (2012) The XmnI and Bcl11A single nucleotide polymorphisms may help predict hydroxyurea response in Iranian β-thalassemia patients. Hemoglobin 36(4): 371-380.

Banan M (2013) Hydroxyurea treatment in β-thalassemia patients: to respond or not to respond? Ann Hematol. 92: 289-299.

Banan M*, Bayat H, Namdar-Aligoodarzi P, Azarkeivan A, Kamali K, Daneshmand P, Zaker-Kandjani B, and Najmabadi H (2013) Utility of the multivariate approach in predicting intermedia or β-thalassemia major types in Iranian patients. Hemoglobin 37(5):  413-422.

Zaker-Kandjani B, Namdar-Aligoodarzi P, Azarkeivan A, Najmabadi H, and Banan M* (2015) Mutation screening of the Krüppel-Like Factor 1 gene by using single-strand conformation polymorphism in a cohort of Iranian β-thalassemia patients. Hemoglobin 39(1): 24-29.

more

 

http://genetic.uswr.ac.ir/index.jsp?siteid=60&fkeyid=&siteid=60&pageid=9761

 

 

Genetics Research Center
Iranome: Iranian Genomic Variations

The human genome is highly variable and each individual’s genome contains approximately 3.5 million Single Nucleotide Polymorphisms (SNPs) and 1000 large (>500 bp) Copy Number Variations (CNVs).

Today, large scale projects such as the 1000 Genomes and the International HapMap projects have been implemented on large scale samples from different populations such as Europeans, Americans, East Asians, and sub-Saharan Africans to increase our understanding of the contribution of genomic variations to human diseases. … more